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VHLL 抗体 (N-Term)

VHLL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2791981
发货至: 中国
  • 抗原 See all VHLL 抗体
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    抗原表位
    • 6
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    宿主
    • 6
    • 3
    克隆类型
    • 7
    • 2
    多克隆
    标记
    • 5
    • 2
    • 1
    • 1
    This VHLL antibody is un-conjugated
    应用范围
    • 6
    • 3
    • 1
    Western Blotting (WB)
    序列
    PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR
    预测反应
    Human: 100%
    产品特性
    This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL
    Top Product
    Discover our top product VHLL Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeat freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    别名
    VHLL (VHLL 产品)
    别名
    VHLP antibody, VLP antibody, VHL like antibody, VHLL antibody
    背景
    Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
    Alias Symbols: VHLP, VLP
    Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
    Protein Size: 139
    分子量
    15 kDa
    基因ID
    391104
    NCBI登录号
    NM_001004319, NP_001004319
    UniProt
    Q6RSH7
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