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- 抗原 See all VHLL 抗体
- VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
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抗原表位
- N-Term
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VHLL antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR
- 预测反应
- Human: 100%
- 产品特性
- This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL
- Top Product
- Discover our top product VHLL Primary Antibody
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anti-Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-139) antibody
VHLL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-139) antibodyVHLL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
- 别名
- VHLL (VHLL 产品)
- 别名
- VHLP antibody, VLP antibody, VHL like antibody, VHLL antibody
- 背景
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Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
Alias Symbols: VHLP, VLP
Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
Protein Size: 139 - 分子量
- 15 kDa
- 基因ID
- 391104
- NCBI登录号
- NM_001004319, NP_001004319
- UniProt
- Q6RSH7
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