8430435N19Rik antibody, BB233594 antibody, GRAP antibody, grap antibody, zgc:110202 antibody, MGC109892 antibody, si:dkeyp-9d4.1 antibody, Grap antibody, GRB2-related adaptor protein antibody, GRB2-related adapter protein antibody, GRB2-related adaptor protein a antibody, GRB2-related adaptor protein b antibody, GRAP antibody, Grap antibody, LOC489534 antibody, grapa antibody, grapb antibody, LOC100727005 antibody
背景
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Alias Symbols: - Protein Interaction Partner: TRIM21, RBPMS, UBC, ARHGAP32, KHDRBS1, LAT, SHC1, SOS1, PLCG1, KIT, LCK, FYN, FASLG, EPOR, GAB2, Protein Size: 217