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- 抗原 See all RRP8 抗体
- RRP8 (Ribosomal RNA Processing 8 (RRP8))
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抗原表位
- N-Term
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适用
- 人, 大鼠, Cow, 马, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RRP8 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- GKKGKKKCQK QGPPCSDSEE EVERKKKCHK QALVGSDSAE DEKRKRKCQK
- 预测反应
- Cow: 83%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 93%
- 产品特性
- This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8
- Top Product
- Discover our top product RRP8 Primary Antibody
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anti-Ribosomal RNA Processing 8 (RRP8) antibody
RRP8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal RNA Processing 8 (RRP8) (Internal Region) antibodyRRP8 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal RNA Processing 8 (RRP8) (AA 1-456) antibodyRRP8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ribosomal RNA Processing 8 (RRP8) (AA 271-320) antibodyRRP8 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal RNA Processing 8 (RRP8) (AA 100-149) antibodyRRP8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal RNA Processing 8 (RRP8) (AA 89-138) antibodyRRP8 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 456 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- RRP8 (Ribosomal RNA Processing 8 (RRP8))
- 别名
- RRP8 (RRP8 产品)
- 别名
- KIAA0409 antibody, 1500003O22Rik antibody, 2900001K19Rik antibody, AW538116 antibody, RGD1308302 antibody, ribosomal RNA processing 8 antibody, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody, RRP8 antibody, Rrp8 antibody
- 背景
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RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Alias Symbols: KIAA0409
Protein Interaction Partner: RNF2, SIRT7, SIRT1, SUV39H1, USP39,
Protein Size: 456 - 分子量
- 50 kDa
- 基因ID
- 23378
- NCBI登录号
- NM_015324, NP_056139
- UniProt
- O43159
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