The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. Alias Symbols: HB5, Hb-5, KRTHB5, hHb5 Protein Interaction Partner: UBC, GRB2, EPS15, CUL3, CUL4B, ATG10, ATG3, MLST8, OTUD4, USPL1, USP15, USP8, ALOX12, LYAR, PLEKHB2, TWF2, YWHAG, DLG3, CDC25B, CDC20, Protein Size: 507