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- 抗原 See all HCAR2 抗体
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠, Cow, 豚鼠, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HCAR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- YYFSSPSFPN FFSTLINRCL QRKMTGEPDN NRSTSVELTG DPNKTRGAPE
- 预测反应
- Cow: 91%, Guinea Pig: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against HCAR2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product HCAR2 Primary Antibody
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibody
HCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 250-350) antibodyHCAR2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 363 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
- 别名
- HCAR2 (HCAR2 产品)
- 别名
- GPR109A antibody, HCA2 antibody, HM74a antibody, HM74b antibody, NIACR1 antibody, PUMAG antibody, Puma-g antibody, Gpr109a antibody, Gpr109b antibody, HM74 antibody, Hcar2 antibody, PUMA-G antibody, Pumag antibody, mHM74b antibody, HCAR2 antibody, HCAR3 antibody, hydroxycarboxylic acid receptor 2 antibody, HCAR2 antibody, Hcar2 antibody, LOC527744 antibody
- 背景
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HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Alias Symbols: HM74a, HM74b, NIACR1, PUMAG, Puma-g
Protein Size: 363 - 分子量
- 42 kDa
- 基因ID
- 338442
- NCBI登录号
- NM_177551, NP_808219
- UniProt
- Q8TDS4
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