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- 抗原 See all SMN2 抗体
- SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, Pig, 兔, 犬, 山羊, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA
- 预测反应
- Dog: 93%, Goat: 82%, Horse: 92%, Human: 100%, Mouse: 79%, Pig: 86%, Rabbit: 85%
- 产品特性
- This is a rabbit polyclonal antibody against SMN2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of SMN2
- Top Product
- Discover our top product SMN2 Primary Antibody
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anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-282) antibody
SMN2 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2B11-2A9 unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 16-251) antibodySMN2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-197) antibodySMN2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) antibodySMN2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-282) antibodySMN2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-197) antibodySMN2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 191-294) antibodySMN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-282) antibodySMN2 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 2, Centromeric (SMN2) (AA 1-294) antibodySMN2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 250 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
- 别名
- SMN2 (SMN2 产品)
- 别名
- BCD541 antibody, C-BCD541 antibody, GEMIN1 antibody, SMNC antibody, TDRD16B antibody, bcd541 antibody, c-bcd541 antibody, gemin-1 antibody, smn2 antibody, smnc antibody, survival of motor neuron 2, centromeric antibody, survival of motor neuron 2, centromeric L homeolog antibody, SMN2 antibody, smn2.L antibody
- 背景
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This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
Alias Symbols: BCD541, C-BCD541, FLJ76644, MGC20996, MGC5208, SMN1, SMNC
Protein Interaction Partner: FAM9B, VPS28, BLOC1S6, CHTOP, HNRNPUL1, POLR1C, PPIG, SMN2, BYSL, WWOX, vpr, UBC, SMN1, RBM25, DDX20, COIL, SRSF5, CUL3, POLR2A, GAR1, SNRPG, SNRPF, SNRPB2, TIAL1, DHX9, GEMIN2, SNRPD1, SNRPD3, SNRPD2, SNRPB, FBL, SNRPE, LRIF1, OSTF1, COPS6, LENG8, STXBP3
Protein Size: 250 - 分子量
- 27 kDa
- 基因ID
- 6607
- NCBI登录号
- NM_022877, NP_075015
- UniProt
- Q16637
- 途径
- Ribonucleoprotein Complex Subunit Organization
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