BRE 抗体 (C-Term)
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- 抗原 See all BRE 抗体
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BRE antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against BRE. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product BRE Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 383 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- 别名
- BRE (BRE 产品)
- 别名
- brcc4 antibody, brcc45 antibody, BRE antibody, LOC100231620 antibody, BRCC4 antibody, BRCC45 antibody, 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, im:7141046 antibody, zgc:110368 antibody, BRISC and BRCA1 A complex member 2 antibody, brain and reproductive organ-expressed (TNFRSF1A modulator) antibody, BRISC and BRCA1 A complex member 2 L homeolog antibody, babam2 antibody, BABAM2 antibody, Babam2 antibody, BRE antibody, babam2.L antibody
- 背景
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BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: FAM175B, UBC, BABAM1, AKAP2, TFG, OPTN, HNRNPA2B1, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, UBD, GFI1B, UIMC1, BRCC3, FAM175A, NCOA3, COPS5, SUMO1, TNFRSF1A, FAS, MMS19, UGGT2, TMX3, DHRS7B, FKBP8, TTC28, ATG2A, SLC25A13, LRPPRC, USP7, SSR3, SHMT2, RPN2, PHB, UB
Protein Size: 383 - 分子量
- 43 kDa
- 基因ID
- 9577
- NCBI登录号
- NM_199194, NP_954664
- UniProt
- Q9NXR7
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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