CD22 抗体 (C-Term)
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- 抗原 See all CD22 抗体
- CD22 (CD22 Molecule (CD22))
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抗原表位
- C-Term
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适用
- 人, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CD22 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- YSALHKRQVG DYENVIPDFP EDEGIHYSEL IQFGVGERPQ AQENVDYVIL
- 预测反应
- Horse: 79%, Human: 100%
- 产品特性
- This is a rabbit polyclonal antibody against CD22. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human CD22
- Top Product
- Discover our top product CD22 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 847 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- CD22 (CD22 Molecule (CD22))
- 别名
- CD22 (CD22 产品)
- 别名
- A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
- 背景
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CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: UBC, CD19, INPP5D, LCP2, AP2M1, SHC1, SYK, PTPN6, PLCG1, PIK3R1, LYN, PTPRC, IGHM, HP, ST6GAL1, ATP2B4, GRB2, AP2A1,
Protein Size: 847 - 分子量
- 95 kDa
- 基因ID
- 933
- NCBI登录号
- NM_001771, NP_001762
- UniProt
- P20273
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