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Presenilin 2 抗体 (C-Term)
PSEN2
适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Saccharomyces cerevisiae
WB
宿主: 兔
Polyclonal
unconjugated
Presenilin 2抗体详情
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抗原
See all Presenilin 2 (PSEN2) 抗体
Presenilin 2 (PSEN2)
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
抗原表位
All epitopes for Presenilin 2 抗体
C-Term
适用
All reactivities for Presenilin 2 抗体
人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Saccharomyces cerevisiae
宿主
All hosts for Presenilin 2 抗体
兔
克隆类型
All clonalities for Presenilin 2 抗体
多克隆
标记
All conjugates for Presenilin 2 抗体
This Presenilin 2 antibody is un-conjugated
应用范围
All applications for Presenilin 2 抗体
Western Blotting (WB)
序列
PYDPEMEEDS YDSFGEPSYP EVFEPPLTGY PGEELEEEEE RGVKLGLGDF
预测反应
Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%, Zebrafish: 100%
产品特性
This is a rabbit polyclonal antibody against PSEN2. It was validated on Western Blot.
纯化方法
Affinity Purified
免疫原
The immunogen is a synthetic peptide directed towards the C-terminal region of human PSEN2
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Discover our top product PSEN2 Primary Antibody
Alternatives
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anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 101-150) antibody
PSEN2
适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Bat, Hamster, Pig, 小鸡
WB, IHC, IHC (p)
宿主: 兔
Polyclonal
unconjugated
使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
1 mg/mL
缓冲液
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeat freeze-thaw cycles.
储存条件
-20 °C
储存方法
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Presenilin 2目标详情
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抗原
Presenilin 2 (PSEN2)
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
别名
PSEN2 (PSEN2 产品 )
别名
AD3L antibody, AD4 antibody, CMD1V antibody, PS2 antibody, STM2 antibody, ALG-3 antibody, Ad4h antibody, Alg3 antibody, PS-2 antibody, Psnl2 antibody, pre2 antibody, zf-PS2 antibody, PSNL2 antibody, PSEN2 antibody, ad4 antibody, ps2 antibody, ad3l antibody, stm2 antibody, Ps2 antibody, presenilin 2 antibody, presenilin 2 S homeolog antibody, presenilin 2 (Alzheimer disease 4) antibody, trefoil factor 1 antibody, PSEN2 antibody, Psen2 antibody, psen2 antibody, psen2.S antibody, Tff1 antibody
背景
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. Alias Symbols: AD4, PS2, AD3L, STM2, CMD1V Protein Size: 304
分子量
33 kDa
基因ID
5664
NCBI登录号
XM_011544236 , XP_011542538
UniProt
E5RG63
途径
Notch Signaling , EGFR Signaling Pathway , Neurotrophin Signaling Pathway
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