PDGFB 抗体 (N-Term)
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- 抗原 See all PDGFB 抗体
- PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
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抗原表位
- N-Term
- 适用
- 人, 大鼠, 小鼠, 犬, Cow, 绵羊, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDGFB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- NRCWALFLSL CCYLRLVSAE GDPIPEELYE MLSDHSIRSF DDLQRLLHGD
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Sheep: 100%
- 产品特性
- This is a rabbit polyclonal antibody against PDGFB. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PDGFB
- Top Product
- Discover our top product PDGFB Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 241 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
- 别名
- PDGFB (PDGFB 产品)
- 背景
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PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.
Alias Symbols: FLJ12858, PDGF2, SIS, SSV, c-sis
Protein Interaction Partner: COL6A1, COL5A1, COL4A1, COL3A1, COL2A1, COL1A2, COL1A1, LYVE1, NRP1, ADIPOQ, MDFI, PDAP1, ART1, PDGFB, HRAS, THBS1, PDGFRA, PDGFRB, HSPG2, LRP1, A2M, SPARC,
Protein Size: 241 - 分子量
- 27 kDa
- 基因ID
- 5155
- NCBI登录号
- NM_002608, NP_002599
- UniProt
- P01127
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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