CEBPA 抗体 (Middle Region)
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- 抗原 See all CEBPA 抗体
- CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, Cow, 斑马鱼, 豚鼠, 犬, 兔, 马, 绵羊
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CEBPA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- RRERNNIAVR KSRDKAKQRN VETQQKVLEL TSDNDRLRKR VEQLSRELDT
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 79%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Zebrafish: 93%
- 产品特性
- This is a rabbit polyclonal antibody against CEBPA. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CEBPA
- Top Product
- Discover our top product CEBPA Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 358 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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House dust mite extract downregulates C/EBP? in asthmatic bronchial smooth muscle cells." in: The European respiratory journal, Vol. 38, Issue 1, pp. 50-8, (2011) (PubMed).
: "Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients." in: The Journal of allergy and clinical immunology, Vol. 123, Issue 3, pp. 639-45, (2009) (PubMed).
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House dust mite extract downregulates C/EBP? in asthmatic bronchial smooth muscle cells." in: The European respiratory journal, Vol. 38, Issue 1, pp. 50-8, (2011) (PubMed).
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- 抗原
- CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
- 别名
- CEBPA (CEBPA 产品)
- 别名
- C/EBP-alpha antibody, CEBP antibody, C/ebpalpha antibody, CBF-A antibody, Cebp antibody, DBPCEP antibody, c/ebpa antibody, cb1062 antibody, wu:fj20f03 antibody, C/EBP antibody, C/EBPalpha antibody, xC/EBP antibody, cC/EBP antibody, C/EBP alpha antibody, CCAAT/enhancer binding protein alpha antibody, CCAAT/enhancer binding protein (C/EBP), alpha antibody, CCAAT/enhancer binding protein alpha L homeolog antibody, CEBPA antibody, Cebpa antibody, cebpa antibody, cebpa.L antibody
- 背景
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CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2385 U34070.1 592-2976
Alias Symbols: C/EBP-alpha, CEBP
Protein Interaction Partner: CEBPB, ZBTB16, RARA, HDAC1, BHLHE41, UBC, CEBPE, BATF2, BATF3, YY1AP1, ATF5, BATF, FOSL1, FOS, DBP, CEBPG, CEBPA, ATF4, ATF3, UBE3A, SKP2, RASGRF1, C1QBP, CDKN1A, SRA1, CDK4, PIAS1, Fbxw7, GRIN3A, RAB34, NAA16, POLR1E, MRTO4, AK5, MACF1, KAT5, AKAP9, SMC1
Protein Size: 358 - 分子量
- 37 kDa
- 基因ID
- 1050
- NCBI登录号
- NM_004364, NP_004355
- UniProt
- P49715
- 途径
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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