PIDD 抗体 (Middle Region)
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- 抗原 See all PIDD 抗体
- PIDD (P53-Induced Death Domain Protein (PIDD))
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抗原表位
- Middle Region
- 适用
- 人, 大鼠, 小鼠, 豚鼠, Cow, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIDD antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE
- 预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human LRDD
- Top Product
- Discover our top product PIDD Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 753 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PIDD (P53-Induced Death Domain Protein (PIDD))
- 别名
- LRDD (PIDD 产品)
- 别名
- 1200011D09Rik antibody, AU042446 antibody, Pidd antibody, LRDD antibody, Lrdd antibody, p53 induced death domain protein 1 antibody, p53-induced death domain protein 1 antibody, Pidd1 antibody, PIDD1 antibody
- 背景
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The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: DKFZp434D229, MGC16925, PIDD, LRDD
Protein Interaction Partner: CRADD, CRYAB, MDFI, SOX8, KEAP1, TEAD3, MAFG, AFP, RPAP3, FANCI, SENP3, TRIM32, ANP32B, HAX1, TELO2, NUP93, AIFM1, RFC5, RFC4, PRKDC, PPP6C, POLR2B, POLD1, PCNA, PRDX1, MCM7, ERCC5, ERCC2, DDB1, CASP2, FADD, RIPK1, IKBKG, CCDC85B, EFEMP2, MADD,
Protein Size: 753 - 分子量
- 83 kDa
- 基因ID
- 55367
- NCBI登录号
- NM_018494, NP_060964
- 途径
- p53 Pathway, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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