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AKTIP 抗体 (Middle Region)

AKTIP 适用: 人, 小鼠, 大鼠, 兔, 犬, 斑马鱼, 马, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2786570
发货至: 中国
  • 抗原 See all AKTIP 抗体
    AKTIP (AKT Interacting Protein (AKTIP))
    抗原表位
    • 30
    • 11
    • 8
    • 8
    • 6
    • 1
    • 1
    Middle Region
    适用
    • 34
    • 30
    • 23
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 兔, 犬, 斑马鱼, 马, Cow, 豚鼠
    宿主
    • 58
    • 6
    克隆类型
    • 61
    • 3
    多克隆
    标记
    • 16
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AKTIP antibody is un-conjugated
    应用范围
    • 53
    • 26
    • 26
    • 26
    • 6
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    序列
    NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%
    产品特性
    This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human AKTIP
    Top Product
    Discover our top product AKTIP Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 292 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

  • 抗原
    AKTIP (AKT Interacting Protein (AKTIP))
    别名
    AKTIP (AKTIP 产品)
    别名
    FT1 antibody, FTS antibody, cb798 antibody, fts antibody, zgc:77699 antibody, fts-A antibody, aktip antibody, fts-B antibody, MGC133931 antibody, AL023020 antibody, Fif antibody, Ft antibody, Ft1 antibody, Fts antibody, AKT interacting protein antibody, akt interacting protein antibody, AKT interacting protein L homeolog antibody, AKT interacting protein S homeolog antibody, thymoma viral proto-oncogene 1 interacting protein antibody, AKTIP antibody, aktip antibody, aktip.L antibody, aktip.S antibody, Aktip antibody
    背景
    AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
    Alias Symbols: FT1, FTS
    Protein Interaction Partner: HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS18, VPS41, TRIM23, TRIM41, MARCH5, DZIP3, KIAA1377, EXOC7, POLA2, GTF3C1, UTP14A, C10orf2, PDPK1, ASS1, CTBP2, IMMT, RPA1, AKT1, TIMM50, PDS5A, IARS, HDLBP, DCTN1,
    Protein Size: 292
    分子量
    33 kDa
    基因ID
    64400
    NCBI登录号
    NM_001012398, NP_001012398
    UniProt
    Q9H8T0
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