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ITGB3BP 抗体 (N-Term)

ITGB3BP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2785998
发货至: 中国
  • 抗原 See all ITGB3BP 抗体
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    抗原表位
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 22
    • 4
    • 3
    • 1
    • 1
    宿主
    • 20
    • 2
    克隆类型
    • 20
    • 2
    多克隆
    标记
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGB3BP antibody is un-conjugated
    应用范围
    • 11
    • 8
    • 7
    • 2
    Western Blotting (WB)
    序列
    TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE
    预测反应
    Human: 100%
    产品特性
    This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP
    Top Product
    Discover our top product ITGB3BP Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 177 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    别名
    ITGB3BP (ITGB3BP 产品)
    别名
    CENP-R antibody, CENPR antibody, HSU37139 antibody, NRIF3 antibody, TAP20 antibody, 4930471O16Rik antibody, AU022583 antibody, integrin subunit beta 3 binding protein antibody, integrin beta 3 binding protein (beta3-endonexin) antibody, ITGB3BP antibody, Itgb3bp antibody
    背景
    ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
    Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
    Protein Interaction Partner: PIH1D2, UBR7, ARFIP2, COL4A3BP, KIFC3, KDM1A, UBC, APP, CENPP, CENPO, SVIL, MAPK6, ACTN2, MTA1, ITGB3BP, DDX24, RECQL5, RXRA, ITGB3, NFKB1, ITGB5, ESR1, CCNA2, THRA, RELA, RXRG,
    Protein Size: 177
    分子量
    20 kDa
    基因ID
    23421
    NCBI登录号
    NM_014288, NP_055103
    UniProt
    Q13352
    途径
    Neurotrophin Signaling Pathway
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