CHMP4B 抗体 (Middle Region)
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- 抗原 See all CHMP4B 抗体
- CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHMP4B antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- EEISTAISKP VGFGEEFDED ELMAELEELE QEELDKNLLE ISGPETVPLP
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against CHMP4B. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CHMP4B
- Top Product
- Discover our top product CHMP4B Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 224 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).
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Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).
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- 抗原
- CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
- 别名
- CHMP4B (CHMP4B 产品)
- 别名
- C20orf178 antibody, CHMP4A antibody, CTPP3 antibody, CTRCT31 antibody, SNF7 antibody, SNF7-2 antibody, Shax1 antibody, VPS32B antibody, Vps32-2 antibody, dJ553F4.4 antibody, 2010012F05Rik antibody, C76846 antibody, Snf7-2 antibody, RGD1309846 antibody, RGD1565889 antibody, CHMP4b antibody, chmp4b antibody, chmp4b.S antibody, CHMP4c antibody, c20orf178 antibody, wu:fc96b02 antibody, zgc:55566 antibody, charged multivesicular body protein 4B antibody, charged multivesicular body protein 4Ba antibody, charged multivesicular body protein 4B L homeolog antibody, charged multivesicular body protein 4Bb antibody, CHMP4B antibody, Chmp4b antibody, chmp4ba antibody, chmp4b.L antibody, chmp4bb antibody
- 背景
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This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Alias Symbols: C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, dJ553F4.4, VPS32B, Vps32-2
Protein Interaction Partner: UBC, TP53, CHMP6, UBE2I, PDCD6IP, VCAM1, ITGA4, RPLP0P6, MVP, ATP6V1B1, BROX, CHMP4B, CHMP4C, CHMP1B, CHMP3, CHMP5, CHMP4A, HIPK2, VPS4A, STAMBP, PIAS2, EXOSC9, HCVgp1, NOLC1, PTPN23,
Protein Size: 224 - 分子量
- 25 kDa
- 基因ID
- 128866
- NCBI登录号
- NM_176812, NP_789782
- UniProt
- Q9H444
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