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FZR1 抗体 (N-Term)

Name: FZR1 抗体 (N-Term)
SKU: ABIN2784494
Availability: OutOfStock

FZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

Host: Rabbit Target Name: FZR1 Sample Type: Human Fetal Heart Antibody Dilution: 1. (FZR1 抗体 (N-Term))

Host: Rabbit Target Name: FZR1 Sample Type: Human Fetal Lung Antibody Dilution: 1. (FZR1 抗体 (N-Term))

WB Suggested Anti-FZR1 Antibody Titration: 0. (FZR1 抗体 (N-Term))

Host: Rabbit Target Name: FZR1 Sample Type: Human Adult Placenta Antibody Dilution: 1. (FZR1 抗体 (N-Term))

Host: Rabbit Target Name: FZR1 Sample Type: Human Fetal Brain Antibody Dilution: 1. (FZR1 抗体 (N-Term))

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(1 reference)

产品编号 ABIN2784494

发货至: 中国

Datasheet as PDF

抗原 See all FZR1 抗体

FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
抗原表位
15

10

8

6

6

1

1

1

1

1

1
N-Term
适用
61

30

14

2

2

2

2

2

2

2

2

1

1

1
人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼
宿主
55

6
兔
Compatible Secondaries
克隆类型
55

6
多克隆
标记
20

5

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This FZR1 antibody is un-conjugated
应用范围
44

23

13

13

5

4

4

3

2

2

1

1
Western Blotting (WB)

序列

SSPVSSPSKH GDRFIPSRAG ANWSVNFHRI NENEKSPSQN RKAKDATSDN

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against FZR1. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1

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Discover our top product FZR1 Primary Antibody
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibody
FZR1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 4C4 unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 141-240) antibody
FZR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-101) antibody
FZR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E12 unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-494) antibody
FZR1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4C4 unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibody
FZR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 224-493) antibody
FZR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-496) antibody
FZR1 适用: 人 WB 宿主: 小鼠 Monoclonal 1621CT637-76-67 unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibody
FZR1 适用: 人, 小鼠, 大鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 35-84) antibody
FZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Pig, Bat, 猴, 小鸡, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibody
FZR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 493 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).
抗原

FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

别名

FZR1 (FZR1 产品)

别名

CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody

背景

FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB
Protein Size: 493

分子量

55 kDa

基因ID

51343

NCBI登录号

NM_016263, NP_057347

UniProt

Q9UM11

途径

DNA Replication, Synthesis of DNA