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UBA3 抗体 (N-Term)

UBA3 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, Pig, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2784205
发货至: 中国
  • 抗原 See all UBA3 抗体
    UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
    抗原表位
    • 9
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 31
    • 21
    • 12
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, Pig, 兔, 马
    宿主
    • 31
    克隆类型
    • 30
    • 1
    多克隆
    标记
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UBA3 antibody is un-conjugated
    应用范围
    • 22
    • 16
    • 14
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    EGRWNHVKKF LERSGPFTHP DFEPSTESLQ FLLDTCKVLV IGAGGLGCEL
    预测反应
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    产品特性
    This is a rabbit polyclonal antibody against UBA3. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human UBA3
    Top Product
    Discover our top product UBA3 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 463 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
    别名
    UBA3 (UBA3 产品)
    别名
    UBE1C antibody, hUBA3 antibody, Ube1c antibody, ube1c antibody, wu:fb75e04 antibody, wu:fc37b11 antibody, zgc:55528 antibody, A830034N06Rik antibody, AI256736 antibody, AI848246 antibody, AW546539 antibody, ubiquitin like modifier activating enzyme 3 antibody, ubiquitin-like modifier activating enzyme 3 antibody, ubiquitin like modifier activating enzyme 3 S homeolog antibody, UBA3 antibody, Uba3 antibody, uba3 antibody, uba3.S antibody
    背景
    UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
    Alias Symbols: DKFZp566J164, MGC22384, UBE1C, hUBA3
    Protein Interaction Partner: UBA3, UBC, IMPA2, CPNE2, NEDD8, CAMK1D, NSFL1C, DCPS, KDM1A, PAPSS1, NAE1, XPO1, PCYT2, CAPN2, AHCY, ACAT2, NT5DC1, NUDCD2, TXNDC17, WDR61, UFC1, DSTN, VCL, UBE2H, PRDX2, TWF1, UBE2M, UIMC1, CHD3,
    Protein Size: 463
    分子量
    52 kDa
    基因ID
    9039
    NCBI登录号
    NM_003968, NP_003959
    UniProt
    Q8TBC4
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