SIGIRR 抗体 (C-Term)
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- 抗原 See all SIGIRR 抗体
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠, 马, 斑马鱼, Cow, 犬, 豚鼠, Pig
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIGIRR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
- 产品特性
- This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
- Top Product
- Discover our top product SIGIRR Primary Antibody
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anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-118) antibody
SIGIRR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-118) antibodySIGIRR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-120) antibodySIGIRR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) antibodySIGIRR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) antibodySIGIRR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H8-2G3 unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, Cow, 犬, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-117) antibodySIGIRR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 334-358) antibodySIGIRR 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠 WB, EIA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 224 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 别名
- SIGIRR (SIGIRR 产品)
- 别名
- TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody
- 背景
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SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alias Symbols: MGC110992, TIR8
Protein Interaction Partner: APP, UBC, SIGIRR, TLR9, TLR5, TLR4, TRAF6, IRAK1, RPN1, IL1R1, ENO2,
Protein Size: 224 - 分子量
- 25 kDa
- 基因ID
- 59307
- UniProt
- Q6IA17
- 途径
- Toll-Like Receptors Cascades
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