NP (Middle Region) 抗体
(1 reference)-
- 抗原
- NP
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, Cow, 兔, Saccharomyces cerevisiae, 犬, 斑马鱼, 豚鼠, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB)
- 序列
- GVDTLVVTNA AGGLNPKFEV GDIMLIRDHI NLPGFSGQNP LRGPNDERFG
- 预测反应
- Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Yeast: 91%, Zebrafish: 79%
- 产品特性
- This is a rabbit polyclonal antibody against NP. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human NP
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anti-NP (Middle Region) antibody
适用: 人, 小鼠, 大鼠, Cow, 兔, Saccharomyces cerevisiae, 犬, 斑马鱼, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-NP (Middle Region) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NP antibody适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 289 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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-
: "Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase." in: Biochemistry, Vol. 47, Issue 8, pp. 2559-64, (2008) (PubMed).
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: "Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase." in: Biochemistry, Vol. 47, Issue 8, pp. 2559-64, (2008) (PubMed).
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- 抗原
- NP
- 物质类
- Viral Protein
- 背景
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Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC117396, MGC125915, MGC125916, PNP, PRO1837, PUNP, NP
Protein Interaction Partner: PNP, UBC, SUMO2, PPME1, SBDS, PSAT1, GMPS, RAB1A, PSMD5, MTAP, ENO2, HECW2, ITGA4, NADK2, TMEM177, DNAJB11, NDUFV1, GLO1, UBD, CDK2, SIRT7, UCHL5, LRIF1, CCDC90B, RBM48, ZHX1, TFB2M, NCALD, TFAM, TP53, APLP1,
Protein Size: 289 - 分子量
- 32 kDa
- 基因ID
- 4860
- NCBI登录号
- NM_000270, NP_000261
- UniProt
- P00491
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