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IDH2 抗体 (Middle Region)

Name: IDH2 抗体 (Middle Region)
SKU: ABIN2783282
Availability: OutOfStock

IDH2 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 斑马鱼, 豚鼠, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-IDH2 Antibody Titration: 0. (IDH2 抗体 (Middle Region))

Western Blotting (WB) image for anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (Middle Region) antibody (ABIN2783282) (IDH2 抗体 (Middle Region))

IDH2 antibody - middle region validated by WB using Proximal kidney tubules purfied from cortex at 1:1000. (IDH2 抗体 (Middle Region))

Host: Rabbit Target Name: IDH2 Sample Tissue: Mouse Small Intestine Antibody Dilution: 1ug/ml (IDH2 抗体 (Middle Region))

4 images

(1 reference)

产品编号 ABIN2783282

发货至: 中国

Datasheet as PDF

抗原 See all IDH2 抗体

IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
抗原表位
16

5

3

2

2

2

2

1

1

1

1

1

1

1

1

1
Middle Region
适用
65

51

41

3

2

1

1

1

1

1

1

1

1

1

1
人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 斑马鱼, 豚鼠, Saccharomyces cerevisiae
宿主
57

7

1
兔
Compatible Secondaries
克隆类型
51

14
多克隆
标记
31

3

3

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This IDH2 antibody is un-conjugated
应用范围
44

19

16

13

13

11

10

7

6

4

3

2

2

1

1

1
Western Blotting (WB)

序列

GGTVFREPII CKNIPRLVPG WTKPITIGRH AHGDQYKATD FVADRAGTFK

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against IDH2. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human IDH2

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anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 40-452) antibody
IDH2 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 193-452) antibody
IDH2 适用: 人 WB, IP, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 1-143) antibody
IDH2 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3E8E9 unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-451) antibody
IDH2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F11 unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 413-447), (C-Term) antibody
IDH2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-452) antibody
IDH2 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F11 unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 251-350) antibody
IDH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 193-452) antibody
IDH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (Internal Region) antibody
Verified IDH2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-451) antibody
IDH2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 452 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Vohwinkel, Lecuona, Sun, Sommer, Vadász, Chandel, Sznajder: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
抗原

IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))

别名

IDH2 (IDH2 产品)

别名

F6P23.14 antibody, F6P23_14 antibody, IDH-II antibody, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 antibody, isocitrate dehydrogenase II antibody, isocitrate dehydrogenase subunit 2 antibody, D2HGA2 antibody, ICD-M antibody, IDH antibody, IDHM antibody, IDP antibody, IDPM antibody, mNADP-IDH antibody, E430004F23 antibody, IDPm antibody, Idh-2 antibody, wu:fb33c06 antibody, wu:fk31e05 antibody, wu:fq43b01 antibody, zgc:55485 antibody, idh2 antibody, IDH2 antibody, isocitrate dehydrogenase subunit 2 antibody, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial antibody, isocitrate dehydrogenase 2 (NADP+), mitochondrial antibody, isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog antibody, isocitrate dehydrogenase [NADP], mitochondrial antibody, IDH2 antibody, Idh2 antibody, idh2.S antibody, idh2 antibody, LOC100441867 antibody

背景

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ICD-M, IDH, IDHM, IDP, mNADP-IDH, IDPM, D2HGA2
Protein Interaction Partner: UBC, SUMO1, NEDD8, MDM2, ADRB2, HDAC1, PYGL, CDK2, SLC2A4,
Protein Size: 452

分子量

47 kDa

基因ID

3418

NCBI登录号

NM_002168, NP_002159

UniProt

P48735

途径

Warburg Effect