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STING/TMEM173 抗体 (Middle Region)

TMEM173 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2783202
发货至: 中国
  • 抗原 See all STING/TMEM173 (TMEM173) 抗体
    STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
    抗原表位
    • 15
    • 13
    • 11
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 65
    • 25
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, Pig
    宿主
    • 79
    • 4
    克隆类型
    • 66
    • 17
    多克隆
    标记
    • 41
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This STING/TMEM173 antibody is un-conjugated
    应用范围
    • 47
    • 26
    • 18
    • 17
    • 13
    • 13
    • 11
    • 9
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL
    预测反应
    Human: 100%, Pig: 83%
    产品特性
    This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human TMEM173
    Top Product
    Discover our top product TMEM173 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 379 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." in: Innate immunity, Vol. 20, Issue 7, pp. 751-9, (2014) (PubMed).

    Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." in: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, (2011) (PubMed).

    Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

  • 抗原
    STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
    别名
    TMEM173 (TMEM173 产品)
    背景
    TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
    Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
    Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
    Protein Size: 379
    分子量
    42 kDa
    基因ID
    340061
    NCBI登录号
    NM_198282, NP_938023
    UniProt
    Q86WV6
    途径
    Activation of Innate immune Response
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