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STING/TMEM173 抗体 (Middle Region)

Name: STING/TMEM173 抗体 (Middle Region)
SKU: ABIN2783202
Availability: OutOfStock

TMEM173 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-TMEM173 Antibody Titration: 0. (STING/TMEM173 抗体 (Middle Region))

Host: Rabbit Target Name: TMEM173 Sample Tissue: Human 786-0 Whole Cell Antibody Dilution: 1ug/ml (STING/TMEM173 抗体 (Middle Region))

2 images

(3 references)

产品编号 ABIN2783202

发货至: 中国

Datasheet as PDF

抗原 See all STING/TMEM173 (TMEM173) 抗体

STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
抗原表位
16

15

13

7

5

3

2

2

2

1

1

1

1

1

1

1

1

1

1
Middle Region
适用
66

25

21

1

1

1

1

1

1

1
人, Pig
宿主
80

4
兔
Compatible Secondaries
克隆类型
69

15
多克隆
标记
40

8

6

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This STING/TMEM173 antibody is un-conjugated
应用范围
48

28

19

19

13

13

11

9

8

5

3

3

1

1

1
Western Blotting (WB)

序列

DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL

预测反应

Human: 100%, Pig: 83%

产品特性

This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human TMEM173

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anti-Transmembrane Protein 173 (TMEM173) (AA 159-373) antibody
TMEM173 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) antibody
TMEM173 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4H8 unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 170-379) antibody
TMEM173 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 284-316), (C-Term) antibody
TMEM173 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) antibody
TMEM173 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 311-340) antibody
TMEM173 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 207-379) antibody
TMEM173 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (Internal Region) antibody
TMEM173 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (C-Term) antibody
TMEM173 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) antibody
TMEM173 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2C9 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 379 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." in: Innate immunity, Vol. 20, Issue 7, pp. 751-9, (2014) (PubMed).

Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." in: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, (2011) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).
抗原

STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

别名

TMEM173 (TMEM173 产品)

背景

TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
Protein Size: 379

分子量

42 kDa

基因ID

340061

NCBI登录号

NM_198282, NP_938023

UniProt

Q86WV6

途径

Activation of Innate immune Response