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STING/TMEM173 抗体 (Middle Region)

Name: STING/TMEM173 抗体 (Middle Region)
SKU: ABIN2783202
Availability: OutOfStock

TMEM173 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-TMEM173 Antibody Titration: 0. (STING/TMEM173 抗体 (Middle Region))

Host: Rabbit Target Name: TMEM173 Sample Tissue: Human 786-0 Whole Cell Antibody Dilution: 1ug/ml (STING/TMEM173 抗体 (Middle Region))

2 images

(3 references)

产品编号 ABIN2783202

发货至: 中国

Datasheet as PDF

抗原 See all STING/TMEM173 (TMEM173) 抗体

STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
抗原表位
20

15

12

8

7

5

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Middle Region
适用
69

25

21

1

1

1

1

1

1

1
人, Pig
宿主
83

4
兔
Compatible Secondaries
克隆类型
73

14
多克隆
标记
39

8

7

5

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This STING/TMEM173 antibody is un-conjugated
应用范围
51

32

23

22

13

13

10

9

8

5

3

3

1

1

1
Western Blotting (WB)

序列

DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL

预测反应

Human: 100%, Pig: 83%

产品特性

This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human TMEM173

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anti-Transmembrane Protein 173 (TMEM173) (AA 159-373) antibody
TMEM173 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 170-379) antibody
TMEM173 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) antibody
TMEM173 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4H8 unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 284-316), (C-Term) antibody
TMEM173 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 311-340) antibody
TMEM173 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 207-379) antibody
TMEM173 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (Internal Region) antibody
TMEM173 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) (C-Term) antibody
TMEM173 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transmembrane Protein 173 (TMEM173) antibody
TMEM173 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2C9 unconjugated

anti-Transmembrane Protein 173 (TMEM173) (AA 160-371) antibody
TMEM173 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 379 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." in: Innate immunity, Vol. 20, Issue 7, pp. 751-9, (2014) (PubMed).

Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." in: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, (2011) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).
抗原

STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

别名

TMEM173 (TMEM173 产品)

别名

ERIS antibody, MITA antibody, MPYS antibody, NET23 antibody, STING antibody, 2610307O08Rik antibody, Mita antibody, RGD1562552 antibody, transmembrane protein 173 antibody, TMEM173 antibody, Tmem173 antibody

背景

TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
Protein Size: 379

分子量

42 kDa

基因ID

340061

NCBI登录号

NM_198282, NP_938023

UniProt

Q86WV6

途径

Activation of Innate immune Response