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- 抗原 See all PLEKHO1 抗体
- PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))
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抗原表位
- N-Term
- 适用
- 人, 大鼠, Pig, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PLEKHO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG
- 预测反应
- Cow: 86%, Human: 100%, Pig: 86%, Rat: 82%
- 产品特性
- This is a rabbit polyclonal antibody against PLEKHO1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PLEKHO1
- Top Product
- Discover our top product PLEKHO1 Primary Antibody
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anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) antibody
PLEKHO1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 1-409) antibodyPLEKHO1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 51-170) antibodyPLEKHO1 适用: 人, 小鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 49-77), (N-Term) antibodyPLEKHO1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19797 unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 143-404) antibodyPLEKHO1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 1-409) antibodyPLEKHO1 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1C7 unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 1-409) antibodyPLEKHO1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3D5 unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (AA 1-410) antibodyPLEKHO1 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1C7 unconjugated
anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) antibodyPLEKHO1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 409 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))
- 别名
- PLEKHO1 (PLEKHO1 产品)
- 别名
- CKIP-1 antibody, OC120 antibody, 2810052M02Rik antibody, Ckip1 antibody, JZA-20 antibody, Jza2 antibody, RGD1311487 antibody, ckip-1 antibody, plekho1 antibody, si:dkey-200h23.2 antibody, pleckstrin homology domain containing O1 antibody, pleckstrin homology domain containing, family O member 1 antibody, pleckstrin homology domain containing, family O member 1a antibody, PLEKHO1 antibody, Plekho1 antibody, plekho1a antibody
- 背景
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PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Alias Symbols: CKIP-1, OC120, RP11-458I7.3
Protein Interaction Partner: PLEKHO1, AKT3, AKT2, AKT1, UBC, GSK3B, TRAF6, Arpc1a, Stub1, Rps3a1, SMURF1, PSMC5, USP7, C10orf88, RPS20, IFI35, DNAJB1, FLNB, CSNK2A1, SMAD5, JUND, JUN, CASP3,
Protein Size: 409 - 分子量
- 46 kDa
- 基因ID
- 51177
- NCBI登录号
- NM_016274, NP_057358
- UniProt
- Q53GL0
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