FBXW7 抗体 (C-Term)
(1 reference)-
- 抗原 See all FBXW7 抗体
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 兔, 斑马鱼, 豚鼠, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FBXW7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against FBXW7. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
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anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 501-600) antibody
FBXW7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 408-707) antibodyFBXW7 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-627) antibodyFBXW7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-707) antibodyFBXW7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibodyFBXW7 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibodyFBXW7 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 兔, 斑马鱼, 豚鼠, 马, Drosophila melanogaster, 猴, 非洲爪蟾, Hamster, 小鸡, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 251-300) antibodyFBXW7 适用: 小鼠, 大鼠, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 177-208), (N-Term) antibodyFBXW7 适用: 人 WB 宿主: 兔 Polyclonal RB51853 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 589 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
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: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
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- 抗原
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- 别名
- FBXW7 (FBXW7 产品)
- 别名
- cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody
- 背景
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FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Alias Symbols: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Protein Interaction Partner: MCL1, CDC34, CCNE1, FBXW7, CUL1, UBE2D1, PIN1, DAB2IP, YAP1, SKP1, MAP4K1, EYA1, KLF5, SREBF1, NOTCH1, UBE2QL1, Creb3l2, Creb3l1, SIC1, CSF3R, KLF2, NCOA3, PTEN, NFE2L1, HSP90AA1, MED11, MED19, MED8, MED30, MED10, MED28, MED29, MED9, MED15, MED31, MED4, M
Protein Size: 707 - 分子量
- 80 kDa
- 基因ID
- 55294
- NCBI登录号
- NM_001013415, NP_001013433
- 途径
- Notch Signaling, EGFR Signaling Pathway
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