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Deoxyuridine Triphosphatase (DUT) (N-Term) 抗体

Name: Deoxyuridine Triphosphatase (DUT) (N-Term) 抗体
SKU: ABIN2782437
Availability: OutOfStock

DUT 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-DUT Antibody Titration: 1 ug/ml Positive Control: Fetal Small Intestine cell lysate (Deoxyuridine Triphosphatase (DUT) (N-Term) 抗体)

Immunohistochemistry (IHC) image for anti-Deoxyuridine Triphosphatase (DUT) (N-Term) antibody (ABIN2782437) (Deoxyuridine Triphosphatase (DUT) (N-Term) 抗体)

IHC

2 images

(1 reference)

产品编号 ABIN2782437

发货至: 中国

Datasheet as PDF

抗原 See all Deoxyuridine Triphosphatase (DUT) 抗体

Deoxyuridine Triphosphatase (DUT)
抗原表位
15

15

13

9

6

3

3

2

1

1

1

1

1

1

1
N-Term
适用
83

32

18

3

2

1

1

1

1

1

1
人
宿主
80

2

1
兔
Compatible Secondaries
克隆类型
82

1
多克隆
标记
28

5

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
非结合性
应用范围
66

26

26

25

22

16

8

6

3
Western Blotting (WB), Immunohistochemistry (IHC)

序列

AAVLSGPGPP LGRAAQHGIP RPLSSAGRLS QGCRGASTVG AAGWKGELPK

预测反应

Human: 100%

产品特性

This is a rabbit polyclonal antibody against DUT. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human DUT

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anti-Deoxyuridine Triphosphatase (DUT) antibody
DUT 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (AA 89-252) antibody
DUT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (Internal Region) antibody
Verified DUT 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (C-Term) antibody
DUT 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (AA 151-252) antibody
DUT 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) antibody
DUT 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (AA 1-252) antibody
DUT 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (C-Term) antibody
DUT 适用: 人, 大鼠, 小鼠, 犬, Bat, 豚鼠, 马, Saccharomyces cerevisiae, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Deoxyuridine Triphosphatase (DUT) (N-Term) antibody
DUT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 252 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Tóth, Varga, Kovács, Málnási-Csizmadia, Vértessy: "Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme." in: The Journal of biological chemistry, Vol. 282, Issue 46, pp. 33572-82, (2007) (PubMed).
抗原

Deoxyuridine Triphosphatase (DUT)

别名

DUT (DUT 产品)

别名

BcDNA:LD08534 antibody, CG4584 antibody, Dmel\\CG4584 antibody, LD08534 antibody, UTPase antibody, anon-SAGE:Wang-077 antibody, dUTPase antibody, Tb07.27E10.390 antibody, dutpase antibody, 5031412I06Rik antibody, 5133400F09Rik antibody, D2Bwg0749e antibody, Dutp antibody, PIP4 antibody, deoxyuridine triphosphatase antibody, Deoxyuridine triphosphatase antibody, dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 antibody, involved in nucleotide metabolism antibody, tegument protein antibody, dUTPase antibody, deoxyuridine triphosphatase L homeolog antibody, DUT antibody, dUTPase antibody, P18 antibody, AlHV1gp51 antibody, UL50 antibody, HVT058 antibody, ORF9 antibody, ORF8 antibody, U45 antibody, GAMMAHV.ORF54 antibody, Tc00.1047053509151.130 antibody, Tc00.1047053508175.160 antibody, Tb927.7.5160 antibody, dut.L antibody, Dut antibody

物质类

Viral Protein

背景

DUT is an essential enzyme of nucleotide metabolism. This protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Alias Symbols: FLJ20622, dUTPase
Protein Interaction Partner: GDI2, NUDT18, PLEKHF2, C19orf25, MRPL14, LEMD3, UBL4A, RPL38, UBC, CUL3, ESRRG, ESRRA, ESR1, SPATA2, DUT, PPARD, PPARA, CDK1,
Protein Size: 252

分子量

19 kDa

基因ID

1854

NCBI登录号

NM_001025248, NP_001020419

UniProt

P33316