KLKB1 抗体 (Middle Region)
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- 抗原 See all KLKB1 抗体
- KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))
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抗原表位
- Middle Region
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适用
- 人, 大鼠, 犬, 马, Pig
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KLKB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS
- 预测反应
- Dog: 86%, Horse: 86%, Human: 100%, Pig: 79%, Rat: 79%
- 产品特性
- This is a rabbit polyclonal antibody against KLKB1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human KLKB1
- Top Product
- Discover our top product KLKB1 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 638 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein." in: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 41077-89, (2005) (PubMed).
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Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein." in: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 41077-89, (2005) (PubMed).
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- 抗原
- KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))
- 别名
- KLKB1 (KLKB1 产品)
- 别名
- KLK3 antibody, PPK antibody, APS antibody, Kal-3 antibody, Kal3 antibody, Klk3 antibody, PSA antibody, KALP15 antibody, Kalp1 antibody, KLKB1 antibody, DKFZp459J2015 antibody, klkb1 antibody, kallikrein B1 antibody, kallikrein B, plasma 1 antibody, plasma kallikrein antibody, Plasma kallikrein antibody, kallikrein B, plasma (Fletcher factor) 1 antibody, coagulation factor XI antibody, kallikrein B1 L homeolog antibody, KLKB1 antibody, Klkb1 antibody, CpipJ_CPIJ004042 antibody, CpipJ_CPIJ014955 antibody, CpipJ_CPIJ020108 antibody, VAA_02266 antibody, LOC100549617 antibody, klkb1 antibody, klkb1.L antibody
- 背景
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Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Alias Symbols: KLK3, PPK
Protein Interaction Partner: TFPI2, HGFAC, SERPINA5, F12, KNG1, IGFBP3, HGF, MST1,
Protein Size: 638 - 分子量
- 28 kDa
- 基因ID
- 3818
- NCBI登录号
- NM_000892, NP_000883
- UniProt
- P03952
- 途径
- Complement System, Brown Fat Cell Differentiation
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