Growth Hormone Receptor 抗体 (N-Term)
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- 抗原 See all Growth Hormone Receptor (GHR) 抗体
- Growth Hormone Receptor (GHR)
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Growth Hormone Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LQSVNPGLKT NSSKEPKFTK CRSPERETFS CHWTDEVHHG TKNLGPIQLF
- 预测反应
- Human: 100%
- 产品特性
- This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GHR
- Top Product
- Discover our top product GHR Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 638 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- Growth Hormone Receptor (GHR)
- 别名
- GHR (GHR 产品)
- 别名
- GHBP antibody, AA986417 antibody, GHR/BP antibody, GHR antibody, ghr antibody, ghr.a antibody, zgc:162141 antibody, growth hormone receptor antibody, growth hormone receptor L homeolog antibody, growth hormone receptor a antibody, GHR antibody, Ghr antibody, ghr.L antibody, ghr antibody, ghra antibody
- 背景
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GHR is a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature.This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GHBP
Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1,
Protein Size: 638 - 分子量
- 70 kDa
- 基因ID
- 2690
- NCBI登录号
- NM_000163, NP_000154
- UniProt
- P10912
- 途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
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