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TRIM32 抗体 (N-Term)

TRIM32 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2780865
发货至: 中国
  • 抗原 See all TRIM32 抗体
    TRIM32 (Tripartite Motif Containing 32 (TRIM32))
    抗原表位
    • 16
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 30
    • 25
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠
    宿主
    • 36
    • 5
    • 1
    克隆类型
    • 40
    • 2
    多克隆
    标记
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRIM32 antibody is un-conjugated
    应用范围
    • 33
    • 14
    • 13
    • 13
    • 9
    • 7
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK
    预测反应
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Rabbit: 93%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against TRIM32. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM32
    Top Product
    Discover our top product TRIM32 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 653 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Streich, Ronchi, Connick, Haas: "Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism." in: The Journal of biological chemistry, Vol. 288, Issue 12, pp. 8209-21, (2013) (PubMed).

    Kudryashova, Wu, Havton, Spencer: "Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component." in: Human molecular genetics, Vol. 18, Issue 7, pp. 1353-67, (2009) (PubMed).

  • 抗原
    TRIM32 (Tripartite Motif Containing 32 (TRIM32))
    别名
    TRIM32 (TRIM32 产品)
    别名
    BBS11 antibody, HT2A antibody, LGMD2H antibody, TATIP antibody, 1810045E12Rik antibody, 3f3 antibody, Zfp117 antibody, tripartite motif containing 32 antibody, tripartite motif-containing 32 antibody, TRIM32 antibody, trim32 antibody, Trim32 antibody
    背景
    TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
    Alias Symbols: HT2A, BBS11, TATIP, LGMD2H
    Protein Interaction Partner: PTPN11, PDE9A, PTCD2, CLIP4, KCTD9, UBQLN1, TRIM32, RABAC1, ABI2, SCGB1A1, UBE2E1, UBE2D1, UBC, TP53, SDCBP, UBE2U, SYT6, MYCN, CEP250, CUL3, GPRASP2, GLIS2, YWHAB, TP73, UBE2D3, UBE2D2, HSP90AA1, SFN, YWHAQ, YWHAZ, YWHAH, YWHAG, YWHAE, NOTCH1, UBD, TOP1,
    Protein Size: 653
    分子量
    72 kDa
    基因ID
    22954
    NCBI登录号
    NM_012210, NP_036342
    UniProt
    Q13049
    途径
    Negative Regulation of intrinsic apoptotic Signaling
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