XBP1 抗体 (N-Term)
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- 抗原 See all XBP1 抗体
- XBP1 (X-Box Binding Protein 1 (XBP1))
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抗原表位
- N-Term
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适用
- 人, Cow, 兔, Pig, 马, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This XBP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- LMVPAQRGAS PEAASGGLPQ ARKRQRLTHL SPEEKALRRK LKNRVAAQTA
- 预测反应
- Cow: 79%, Dog: 83%, Horse: 79%, Human: 100%, Pig: 93%, Rabbit: 92%
- 产品特性
- This is a rabbit polyclonal antibody against XBP1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human XBP1
- Top Product
- Discover our top product XBP1 Primary Antibody
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anti-X-Box Binding Protein 1 (XBP1) (AA 300-376) antibody
XBP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) antibodyXBP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 51-150) antibodyXBP1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (Internal Region) antibodyVerified XBP1 适用: 人 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-167) antibodyXBP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 123-225) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21824 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 261 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- XBP1 (X-Box Binding Protein 1 (XBP1))
- 别名
- XBP1 (XBP1 产品)
- 背景
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XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Alias Symbols: TREB5, XBP2
Protein Interaction Partner: DERL1, UBE2I, HM13, XBP1, CREBZF, ATF6, ATF6B, UBC, SUMO2, PSMA8, PSMA6, PSMA5, ZNF440, PCBD2, ZNF580, TRIP4, H1FX, FUBP3, NR0B2, SSX4, SRSF1, RBL2, HDGF, H1F0, GLI1, IRE1, FOS, ESR1, FOXA1, POLR2A,
Protein Size: 261 - 分子量
- 29 kDa
- 基因ID
- 7494
- NCBI登录号
- NM_005080, NP_005071
- UniProt
- P17861
- 途径
- ER-Nucleus Signaling, Unfolded Protein Response
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