RCAN1 抗体 (Middle Region)
(1 reference)-
- 抗原 See all RCAN1 抗体
- RCAN1 (Regulator of Calcineurin 1 (RCAN1))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 绵羊, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RCAN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PVINYDLLYA ISKLGPGEKY ELHAATDTTP SVVVHVCESD QEKEEEEEME
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 79%
- 产品特性
- This is a rabbit polyclonal antibody against RCAN1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human RCAN1
- Top Product
- Discover our top product RCAN1 Primary Antibody
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anti-Regulator of Calcineurin 1 (RCAN1) (AA 60-245) antibody
RCAN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibodyRCAN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) antibodyRCAN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibodyRCAN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibodyRCAN1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-117) antibodyRCAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibodyRCAN1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 41-68), (N-Term) antibodyRCAN1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB36242 unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 75-104) antibodyRCAN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Regulator of Calcineurin 1 (RCAN1) (AA 222-252) antibodyRCAN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 252 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).
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: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).
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- 抗原
- RCAN1 (Regulator of Calcineurin 1 (RCAN1))
- 别名
- RCAN1 (RCAN1 产品)
- 别名
- ADAPT78 antibody, CSP1 antibody, DSC1 antibody, DSCR1 antibody, MCIP1 antibody, RCN1 antibody, RCAN1 antibody, 2410048A02Rik antibody, AA408855 antibody, AI429645 antibody, AL024459 antibody, AV028423 antibody, Adapt78 antibody, CALP1L antibody, Dscr1 antibody, Mcip1 antibody, dscr1 antibody, rcan1 antibody, wu:fr92c05 antibody, adapt78 antibody, csp1 antibody, dsc1 antibody, mcip1 antibody, MGC53636 antibody, rcn1 antibody, MGC69428 antibody, regulator of calcineurin 1 antibody, regulator of calcineurin 1b antibody, regulator of calcineurin 1 L homeolog antibody, Down syndrome critical region gene 1 antibody, RCAN1 antibody, Rcan1 antibody, rcan1b antibody, rcan1.L antibody, dscr1 antibody, rcan1 antibody
- 背景
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RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Protein Interaction Partner: UBC, PPP3CA, NEDD8, APP, FBXW11, BTRC, FBXW4, TOLLIP, TRAF6, IRAK1, HSP90AA1, STAT2, GSK3B, MAP3K3, MAPK3, UXT,
Protein Size: 252 - 分子量
- 28 kDa
- 基因ID
- 1827
- NCBI登录号
- NM_004414, NP_004405
- UniProt
- P53805
- 途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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