电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

RCAN1 抗体 (Middle Region)

RCAN1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 绵羊, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2780590
发货至: 中国
  • 抗原 See all RCAN1 抗体
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    抗原表位
    • 15
    • 11
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 78
    • 19
    • 17
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 绵羊, 兔, 斑马鱼
    宿主
    • 73
    • 5
    • 1
    克隆类型
    • 77
    • 2
    多克隆
    标记
    • 38
    • 7
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RCAN1 antibody is un-conjugated
    应用范围
    • 62
    • 38
    • 13
    • 13
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB)
    序列
    PVINYDLLYA ISKLGPGEKY ELHAATDTTP SVVVHVCESD QEKEEEEEME
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 79%
    产品特性
    This is a rabbit polyclonal antibody against RCAN1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human RCAN1
    Top Product
    Discover our top product RCAN1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 252 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Voronov, Ochotny, Jaumouillé, Owen, Manolson, Aubin: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).

  • 抗原
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    别名
    RCAN1 (RCAN1 产品)
    别名
    ADAPT78 antibody, CSP1 antibody, DSC1 antibody, DSCR1 antibody, MCIP1 antibody, RCN1 antibody, RCAN1 antibody, 2410048A02Rik antibody, AA408855 antibody, AI429645 antibody, AL024459 antibody, AV028423 antibody, Adapt78 antibody, CALP1L antibody, Dscr1 antibody, Mcip1 antibody, dscr1 antibody, rcan1 antibody, wu:fr92c05 antibody, adapt78 antibody, csp1 antibody, dsc1 antibody, mcip1 antibody, MGC53636 antibody, rcn1 antibody, MGC69428 antibody, regulator of calcineurin 1 antibody, regulator of calcineurin 1b antibody, regulator of calcineurin 1 L homeolog antibody, Down syndrome critical region gene 1 antibody, RCAN1 antibody, Rcan1 antibody, rcan1b antibody, rcan1.L antibody, dscr1 antibody, rcan1 antibody
    背景
    RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
    Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
    Protein Interaction Partner: UBC, PPP3CA, NEDD8, APP, FBXW11, BTRC, FBXW4, TOLLIP, TRAF6, IRAK1, HSP90AA1, STAT2, GSK3B, MAP3K3, MAPK3, UXT,
    Protein Size: 252
    分子量
    28 kDa
    基因ID
    1827
    NCBI登录号
    NM_004414, NP_004405
    UniProt
    P53805
    途径
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
You are here:
客服