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JunB 抗体 (N-Term)

JUNB 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2780413
发货至: 中国
  • 抗原 See all JunB (JUNB) 抗体
    JunB (JUNB) (Jun B Proto-Oncogene (JUNB))
    抗原表位
    • 29
    • 15
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    • 12
    • 7
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    N-Term
    适用
    • 131
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    人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠
    宿主
    • 123
    • 7
    • 1
    克隆类型
    • 117
    • 14
    多克隆
    标记
    • 65
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    This JunB antibody is un-conjugated
    应用范围
    • 87
    • 41
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    • 16
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    • 6
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    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    YGRAPGGLSL HDYKLLKPSL AVNLADPYRS LKAPGARGPG PEGGGGGSYF
    预测反应
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against JUNB. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human JUNB
    Top Product
    Discover our top product JUNB Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 347 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Trøen, Nygaard, Jenssen, Ikonomou, Tierens, Matutes, Gruszka-Westwood, Catovsky, Myklebost, Lauritzsen, Hovig, Delabie: "Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma." in: The Journal of molecular diagnostics : JMD, Vol. 6, Issue 4, pp. 297-307, (2004) (PubMed).

  • 抗原
    JunB (JUNB) (Jun B Proto-Oncogene (JUNB))
    别名
    JUNB (JUNB 产品)
    别名
    AP-1 antibody, junb antibody, wu:cegs2778 antibody, wu:fa92h07 antibody, wu:fq24h03 antibody, zgc:64066 antibody, MGC81322 antibody, JUNB antibody, junbl antibody, wu:fa95h09 antibody, wu:fj44e11 antibody, wu:fj68b07 antibody, zgc:63933 antibody, JunB proto-oncogene, AP-1 transcription factor subunit antibody, JunB proto-oncogene, AP-1 transcription factor subunit a antibody, jun B proto-oncogene L homeolog antibody, jun B proto-oncogene antibody, jun B proto-oncogene S homeolog antibody, JunB proto-oncogene, AP-1 transcription factor subunit b antibody, JUNB antibody, Junb antibody, junba antibody, junb.L antibody, junb antibody, junb.S antibody, junbb antibody
    背景
    The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
    Alias Symbols: AP-1
    Protein Interaction Partner: BATF, FOS, RFWD2, C19orf68, USP24, TCERG1, ZNF595, PKIA, MAP2, APLP2, FOSL1, DDIT3, ATF3, BATF2, BATF3, TCL1A, FOSL2, NPM1, NEU1, SMAD4, HOXA7, BDNF, ATF4, MAPK6, UBC, TDG, SET, SAT1, MAPK9, BRCA1, SUMO2, Cebpb, EP300, SMURF1, YY1, CREBBP, SMARCA4, JDP2,
    Protein Size: 347
    分子量
    36 kDa
    基因ID
    3726
    NCBI登录号
    NM_002229, NP_002220
    UniProt
    P17275
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