APEX1 抗体 (N-Term)
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- 抗原 See all APEX1 抗体
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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抗原表位
- N-Term
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适用
- 小鼠, 大鼠, Cow, 兔, 马, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This APEX1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MPKRGKKAAA DDGEEPKSEP ETKKSKGAAK KTEKEAAGEG PVLYEDPPDQ
- 预测反应
- Cow: 85%, Guinea Pig: 86%, Horse: 79%, Mouse: 100%, Rabbit: 86%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against APEX1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Top Product
- Discover our top product APEX1 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 317 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- 别名
- APEX1 (APEX1 产品)
- 背景
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
Alias Symbols: APE, Apex, HAP1, Ref-1
Protein Interaction Partner: Pcna, Gadd45a, Eed, Mutyh, Plcb1, Hdac1, Sin3a, Hdac2,
Protein Size: 317 - 分子量
- 35 kDa
- 基因ID
- 11792
- NCBI登录号
- NM_009687, NP_033817
- UniProt
- Q544Z7
- 途径
- DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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