PTK2B 抗体 (C-Term)
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- 抗原 See all PTK2B 抗体
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, 兔, Pig, 马, Cow, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTK2B antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KSPLTPEKEV GYLEFTGPPQ KPPRLGAQSI QPTANLDRTD DLVYLNVMEL
- 预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against PTK2B. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human PTK2B
- Top Product
- Discover our top product PTK2B Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 1009 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).
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The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).
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- 抗原
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- 别名
- PTK2B (PTK2B 产品)
- 背景
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PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
Alias Symbols: PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
Protein Interaction Partner: CBLB, UBC, EGFR, PXN, HSP90AA1, MAPT, GP6, TRAF4, BCAR1, SKAP2, GP1BB, UL49, SOCS3, SRC, GRB2, FYN, DNM1, ALG2, SH3KBP1, PDCD6IP, CBL, SOCS2, PTEN, MBD2, DLGAP3, STAP1, SORBS2, NEDD9, EFS, NPHP1, PITPNM2, PITPNM3, PITPNM1, ARHGAP21, RB1CC1, ASAP1, LPXN, P
Protein Size: 1009 - 分子量
- 116 kDa
- 基因ID
- 2185
- NCBI登录号
- NM_004103, NP_004094
- UniProt
- Q14289
- 途径
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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