(1 reference)-
- 抗原 See all PITX2 抗体
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 马, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PITX2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS
- 预测反应
- Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%
- 产品特性
- This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
- Top Product
- Discover our top product PITX2 Primary Antibody
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anti-Paired-Like Homeodomain 2 (PITX2) (AA 40-154) antibody
PITX2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibodyPITX2 适用: 人, 大鼠, 小鼠, Pig, 兔, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-271) antibodyPITX2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 20-69) antibodyPITX2 适用: 人, 小鼠, Pig, Cow, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 122-151) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) antibodyPITX2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 189-270) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 317 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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- 抗原
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
- 别名
- PITX2 (PITX2 产品)
- 背景
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The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 317 - 分子量
- 35 kDa
- 基因ID
- 5308
- NCBI登录号
- NM_153426, NP_700475
- UniProt
- Q99697
- 途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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