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SIRT6 抗体 (Middle Region)

Name: SIRT6 抗体 (Middle Region)
SKU: ABIN2779624
Availability: OutOfStock

SIRT6 适用: 人, 大鼠, 犬, Cow WB, IP, ChIP 宿主: 兔 Polyclonal unconjugated

IP: 5 ul in 1ml of U2OS lysates (SIRT6 抗体 (Middle Region))

Image no. 1 for anti-Sirtuin 6 (SIRT6) (Middle Region) antibody (ABIN2779624) (SIRT6 抗体 (Middle Region))

WB Suggested Anti-SIRT6 Antibody Titration: 0. (SIRT6 抗体 (Middle Region))

3 images

(2 references)

产品编号 ABIN2779624

发货至: 中国

Datasheet as PDF

抗原 See all SIRT6 抗体

SIRT6 (Sirtuin 6 (SIRT6))
抗原表位
15

15

6

6

5

5

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Middle Region
适用
87

30

14

4

3

2

2

1

1

1

1

1
人, 大鼠, 犬, Cow
宿主
82

13

2
兔
Compatible Secondaries
克隆类型
79

18
多克隆
标记
49

11

6

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This SIRT6 antibody is un-conjugated
应用范围
77

37

32

14

14

9

8

7

6

5

4

2

2

2
Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

序列

TRINGSIPAG PKQEPCAQHN GSEPASPKRE RPTSPAPHRP PKRVKAKAVP

预测反应

Cow: 100%, Dog: 100%, Human: 100%, Rat: 83%

产品特性

This is a rabbit polyclonal antibody against SIRT6. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human SIRT6

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anti-Sirtuin 6 (SIRT6) (N-Term) antibody
SIRT6 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 6 (SIRT6) (AA 35-274) antibody
SIRT6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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SIRT6 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated

anti-Sirtuin 6 (SIRT6) (AA 56-105) antibody
SIRT6 适用: 人, 小鼠, 犬, 猴, Pig, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 6 (SIRT6) (C-Term) antibody
SIRT6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 6 (SIRT6) (C-Term) antibody
SIRT6 适用: 人, 大鼠, 犬, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 6 (SIRT6) (C-Term) antibody
SIRT6 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 355 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Wajapeyee, Malonia, Palakurthy, Green: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." in: Genes & development, Vol. 27, Issue 20, pp. 2221-6, (2013) (PubMed).

Gazin, Wajapeyee, Gobeil, Virbasius, Green: "An elaborate pathway required for Ras-mediated epigenetic silencing." in: Nature, Vol. 449, Issue 7165, pp. 1073-7, (2007) (PubMed).
抗原

SIRT6 (Sirtuin 6 (SIRT6))

别名

SIRT6 (SIRT6 产品)

别名

2810449N18Rik antibody, AI043036 antibody, Sir2l6 antibody, SIR2L6 antibody, zgc:86729 antibody, sirtuin 6 antibody, sirtuin 6 S homeolog antibody, Sirt6 antibody, SIRT6 antibody, sirt6.S antibody, sirt6 antibody

背景

SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: SIR2L6
Protein Interaction Partner: UBC, MDM2, AKT1, STUB1, SKP2, ABCF2, FAF1, VIM, UBE2D1, CHD3, NR0B2, tat, CCNDBP1, RELA, XRCC5, PRKDC, XRCC6, ELF5,
Protein Size: 355

分子量

39 kDa

基因ID

51548

NCBI登录号

NM_016539, NP_057623

UniProt

Q8N6T7