ERCC8 抗体 (N-Term)
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- 抗原 See all ERCC8 抗体
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 犬, 兔, Cow, Pig, 豚鼠, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERCC8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- DVERIHGGGI NTLDIEPVEG RYMLSGGSDG VIVLYDLENS SRQSYYTCKA
- 预测反应
- Cow: 77%, Dog: 85%, Guinea Pig: 77%, Human: 100%, Mouse: 85%, Pig: 85%, Rabbit: 85%, Rat: 77%, Zebrafish: 85%
- 产品特性
- This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC8
- Top Product
- Discover our top product ERCC8 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 396 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- 别名
- ERCC8 (ERCC8 产品)
- 别名
- zgc:103550 antibody, CKN1 antibody, CSA antibody, UVSS2 antibody, Ckn1 antibody, 2410022P04Rik antibody, 2810431L23Rik antibody, 4631412O06Rik antibody, B130065P18Rik antibody, Csa antibody, excision repair cross-complementation group 8 antibody, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antibody, excision repaiross-complementing rodent repair deficiency, complementation group 8 antibody, ercc8 antibody, ERCC8 antibody, Ercc8 antibody
- 背景
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
Protein Size: 396 - 分子量
- 44 kDa
- 基因ID
- 1161
- NCBI登录号
- NM_000082, NP_000073
- UniProt
- Q13216
- 途径
- DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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