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Calreticulin 抗体 (C-Term)

Name: Calreticulin 抗体 (C-Term)
SKU: ABIN182340
Availability: OutOfStock

CALR 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 马, 斑马鱼, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-CALR Antibody Titration: 1. (Calreticulin 抗体 (C-Term))

1 image

产品编号 ABIN182340

发货至: 中国

Datasheet as PDF

抗原 See all Calreticulin (CALR) 抗体

Calreticulin (CALR)
抗原表位
16

12

8

7

6

4

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
125

63

46

10

9

7

7

6

5

4

4

4

3

1

1

1

1

1
人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 马, 斑马鱼, Saccharomyces cerevisiae
宿主
119

9

2

1
兔
Compatible Secondaries
克隆类型
113

18
多克隆
标记
64

13

11

7

5

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Calreticulin antibody is un-conjugated
应用范围
101

52

47

37

28

23

22

16

14

13

3

2

2

2

1

1

1

1

1

1
Western Blotting (WB)

序列

KEEEEDKKRK EEEEAEDKED DEDKDEDEED EEDKEEDEEE DVPGQAKDEL

预测反应

Cow: 86%, Dog: 92%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 93%, Rat: 86%, Yeast: 86%, Zebrafish: 85%

产品特性

This is a rabbit polyclonal antibody against CALR. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Protein A purified

免疫原

The immunogen is a synthetic peptide directed towards the C terminal region of human CALR

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anti-Calreticulin (CALR) (AA 18-193) antibody
CALR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) antibody
CALR 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 1G6A7 unconjugated

anti-Calreticulin (CALR) (AA 18-417) antibody
CALR 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7B3D7 unconjugated

anti-Calreticulin (CALR) (AA 1-417) antibody
CALR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G11-1A9 unconjugated

anti-Calreticulin (CALR) (N-Term) antibody
CALR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) antibody
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) (AA 277-305) antibody
CALR 适用: 人, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21112 unconjugated

anti-Calreticulin (CALR) antibody (HRP)
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal HRP

anti-Calreticulin (CALR) antibody (FITC)
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal FITC

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 417 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

Calreticulin (CALR)

别名

CALR (CALR 产品)

背景

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
Alias Symbols: RO, CRT, SSA, cC1qR
Protein Interaction Partner: HUWE1, UBC, LGR4, MDM2, RNF2, SUZ12, rev, AARSD1, THG1L, NSUN2, SH3GLB1, EEF2K, ARPC1A, ANP32B, ACTR2, ARPC1B, ARPC3, ARPC5, TPD52L2, SH3GL1, RPA3, RPA1, PRKACA, PFDN5, LPP, PARK2, UPF2, UBD, SOX2, PDIA3, CLN5, ITGA3, HLA-E, HLA-A, CALR, SLC27A2, env, MTN
Protein Size: 417

分子量

48 kDa

基因ID

811

NCBI登录号

NM_004343, NP_004334

UniProt

P27797

途径

Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response