U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody, U2AF1-RS3 antibody, U2AF1-like 4 antibody, U2AF1-like protein 3 antibody, U2AF1L3 antibody, U2AF1L3V1 antibody, U2AF1RS3 antibody, U2af26 antibody, AA407033 antibody, AF419339 antibody, AI451269 antibody, AW553050 antibody, TMEM149 antibody, U2 small nuclear RNA auxiliary factor 1 like 4 antibody, U2 small nuclear RNA auxiliary factor 1-like 4 antibody, U2AF1L4 antibody, U2af1l4 antibody
背景
U2AF1L4 is a RNA-binding protein that function as a pre-mRNA splicing factor. It plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It acts by enhancing the binding of U2AF2 to weak pyrimidine tracts and also participates in the regulation of alternative pre-mRNA splicing. It activates exon 5 skipping of PTPRC during T-cell activation, an event reversed by GFI1. U2AF1L4 binds to RNA at the AG dinucleotide at the 3'-splice site. Protein Interaction Partner: MDM2, SUZ12, UBC, ELAVL1, GIGYF2, Protein Size: 220