INSIG1 抗体 (Middle Region)
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- 抗原 See all INSIG1 抗体
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, 马, 兔, Cow, 山羊, 豚鼠, 绵羊, 犬, Pig, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This INSIG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
- 预测反应
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 87%
- 产品特性
- This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
- Top Product
- Discover our top product INSIG1 Primary Antibody
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anti-Insulin Induced Gene 1 (INSIG1) (AA 1-87) antibody
INSIG1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Internal Region) antibodyINSIG1 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 63-112) antibodyINSIG1 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 山羊, 豚鼠, 犬, Pig, 猴, Hamster, 非洲爪蟾, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 36-63), (N-Term) antibodyINSIG1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21689 unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 山羊, 豚鼠, 绵羊, 犬, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 71-120) antibodyINSIG1 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 山羊, 绵羊, Pig, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 225 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- 别名
- INSIG1 (INSIG1 产品)
- 别名
- cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
- 背景
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC26273, INSIG1
Protein Interaction Partner: RNF5, HMGCR, SCAP, SREBF1, RNF139, UBQLN1, UBQLN2, FAF2, ADRM1, PSMD14, BAG6, VCP, UBC, RPN1, PSMD13, PSMD12, PSMD11, PSMD4, PSMC6, PSMC5, PSMC3, PSMC2, PSMB3, PSMB1, PSMA7, PSMA2, LGALS7, JUP, INSIG1, HSPA8, HSPA6, HSPA5, HSPA1A, ENO1, DSP, AMFR, SREBF2,
Protein Size: 225 - 分子量
- 25 kDa
- 基因ID
- 51141
- NCBI登录号
- NM_016133, NP_057217
- UniProt
- Q9Y5U4
- 途径
- ER-Nucleus Signaling
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