IKZF3 is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. Protein Interaction Partner: STAMBPL1, EXOSC5, LGALS14, CABP5, PCID2, RCOR3, TBC1D22B, FANCL, MAGOHB, C1orf109, OAZ3, SPG21, CHCHD2, OSGIN1, POLM, PPP1R16B, ABLIM3, IKZF3, NEK6, FARS2, MRPL28, KAT5, BCAS2, AKAP9, FAM115A, EMC2, POLR1C, STX11, STK16, RAD51D, PSMA1, PRKAB2, PRKAA1, PIN Protein Size: 263