XRCC4 抗体 (Middle Region)
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- 抗原 See all XRCC4 抗体
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
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抗原表位
- Middle Region
- 适用
- 人, 大鼠, 小鼠, Cow, 豚鼠, 马, 斑马鱼, 犬, 兔, Saccharomyces cerevisiae
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This XRCC4 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LQKENERLLR DWNDVQGRFE KCVSAKEALE TDLYKRFILV LNEKKTKIRS
- 预测反应
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Yeast: 77%, Zebrafish: 85%
- 产品特性
- This is a rabbit polyclonal antibody against XRCC4. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human XRCC4
- Top Product
- Discover our top product XRCC4 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 336 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
- 别名
- XRCC4 (XRCC4 产品)
- 别名
- zgc:73312 antibody, MGC81443 antibody, homolog of human DNA ligase iv-binding protein XRCC4 antibody, 2310057B22Rik antibody, AW413319 antibody, AW545101 antibody, X-ray repair cross complementing 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog antibody, DNA ligase IV-binding protein antibody, XRCC4 antibody, xrcc4 antibody, xrcc4.L antibody, Xrcc4 antibody
- 背景
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XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes.The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.
Alias Symbols: -
Protein Interaction Partner: BIN1, FAM9B, ASTE1, XRCC4, LIG4, PNKP, PRKDC, CSNK2A1, VPS41, NUDT21, CWC27, DENR, USP7, SRP54, DDX5, APTX, ERG, SUMO2, UBC, CALM1, XRCC5, XRCC6, SETMAR, AHNAK, CAAP1, IFFO1, APLF, CHD3, NHEJ1, VIM, GZMB, ACTN1, NBN,
Protein Size: 336 - 分子量
- 38 kDa
- 基因ID
- 7518
- NCBI登录号
- NM_022406, NP_071801
- UniProt
- Q13426
- 途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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