LIG4 抗体 (N-Term)
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- 抗原 See all LIG4 抗体
- LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LIG4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- DGERMQMHKD GDVYKYFSRN GYNYTDQFGA SPTEGSLTPF IHNAFKADIQ
- 预测反应
- Cow: 92%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 93%
- 产品特性
- This is a rabbit polyclonal antibody against LIG4. It was validated on Western Blot and immunohistochemistry.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human LIG4
- Top Product
- Discover our top product LIG4 Primary Antibody
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anti-Ligase IV, DNA, ATP-Dependent (LIG4) (C-Term) antibody
LIG4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (AA 612-911) antibodyLIG4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (AA 802-911) antibodyLIG4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (AA 275-324) antibodyLIG4 适用: 人, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) antibodyKO Validated LIG4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (N-Term) antibodyLIG4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (Center) antibodyLIG4 适用: 人, Cow, 犬 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) antibodyLIG4 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ligase IV, DNA, ATP-Dependent (LIG4) (AA 1-911) antibodyLIG4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 911 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
- 别名
- LIG4 (LIG4 产品)
- 别名
- zgc:165595 antibody, lig4 antibody, DNA LIGASE IV antibody, LIG4 antibody, lig4-A antibody, 5830471N16Rik antibody, tiny antibody, DNL4 antibody, ligase IV, DNA, ATP-dependent antibody, DNA ligase 4 antibody, ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining antibody, DNA ligase IV antibody, ligase IV, DNA, ATP-dependent L homeolog antibody, lig4 antibody, LIG4 antibody, LOC100212302 antibody, CpipJ_CPIJ005161 antibody, PTRG_09982 antibody, MCYG_05151 antibody, LOC657210 antibody, ATLIG4 antibody, lig4.L antibody, Lig4 antibody
- 背景
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LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
Protein Interaction Partner: XRCC4, UBC, AGO2, GZMK, ZSCAN18, PHF10, PNKP, TSFM, PRKDC, GUSBP3, NOMO3, FBLL1, PGP, ASPM, AMZ2P1, PPP1R18, COMMD1, ZNF428, AGAP4, WDR20, RPS19BP1, ZFAND2A, FIP1L1, CCDC176, VKORC1, COA7, SOWAHC, SEMA4G, ALMS1, WARS, UBE2L3, UBB, TPT1, TPI1, TP53BP1, TLE
Protein Size: 911 - 分子量
- 104 kDa
- 基因ID
- 3981
- NCBI登录号
- NM_002312, NP_002303
- UniProt
- Q8IY66
- 途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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