ATXN7 抗体 (Middle Region)
(1 reference)-
- 抗原 See all ATXN7 抗体
- ATXN7 (Ataxin 7 (ATXN7))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, Cow, Pig
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATXN7 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- TRSLTCKTHS LTQRRAVQGR RKRFDVLLAE HKNKTREKEL IRHPDSQQPP
- 预测反应
- Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 92%
- 产品特性
- This is a rabbit polyclonal antibody against ATXN7. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human ATXN7
- Top Product
- Discover our top product ATXN7 Primary Antibody
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anti-Ataxin 7 (ATXN7) (AA 402-503) antibody
ATXN7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 7 (ATXN7) antibodyATXN7 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 7 (ATXN7) (Internal Region) antibodyATXN7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 7 (ATXN7) (AA 359-408) antibodyATXN7 适用: 人, 小鼠, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 7 (ATXN7) (Middle Region) antibodyATXN7 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 892 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).
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: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).
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- 抗原
- ATXN7 (Ataxin 7 (ATXN7))
- 别名
- ATXN7 (ATXN7 产品)
- 别名
- MGC82940 antibody, ADCAII antibody, OPCA3 antibody, SCA7 antibody, A430107N12Rik antibody, AI627028 antibody, Sca7 antibody, ataxin-7 antibody, RGD1562692 antibody, ataxin 7 L homeolog antibody, ataxin 7 antibody, atxn7.L antibody, atxn7 antibody, ATXN7 antibody, Atxn7 antibody
- 背景
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ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Alias Symbols: ADCAII, OPCA3, SCA7
Protein Interaction Partner: VCP, USP22, PICK1, TP53BP2, RAD23A, ATXN7L3, ENY2, PIAS1, SUMO1, UBE2I, SUMO2, KAT2A, AGRN, LRSAM1, ADAM33, CEP70, COG6, TRIM54, CEP72, RNF31, PPP1R12C, CRIM1, TXNDC11, EFEMP2, UBQLN2, CARD10, NOC2L, NUP62, MPRIP, SPRY1, GPRASP1, PNMA1, RABEP1, KALRN, LTB
Protein Size: 892 - 分子量
- 95 kDa
- 基因ID
- 6314
- NCBI登录号
- NM_000333, NP_000324
- UniProt
- O15265
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