CTCF 抗体 (C-Term)
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- 抗原 See all CTCF 抗体
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, Cow, 犬, 兔, Pig, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CTCF antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- HADNCAGPDG VEGENGGETK KSKRGRKRKM RSKKEDSSDS ENAEPDLDDN
- 预测反应
- Cow: 100%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against CTCF. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human CTCF
- Top Product
- Discover our top product CTCF Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 727 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
- 别名
- CTCF (CTCF 产品)
- 背景
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This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
Alias Symbols: -
Protein Interaction Partner: ZMYM4, UBC, EED, BMI1, KANSL1, CDK19, ZMYM2, CAND1, ZBTB33, TFAP4, SUMO1, SUMO2, SUMO3, SIRT7, TAF3, SMC3, POLR2A, SUZ12, Ctcf, HIST2H2AC, TOP2A, TAF1, NPM1, LMNA, KPNA4, KPNA2, H2AFZ, PARP1, TRB, RXRA, SMAD3, SIN3A, SMC1A, RAD21, YY1, THRB, SMAD4, HMGB1,
Protein Size: 727 - 分子量
- 83 kDa
- 基因ID
- 10664
- NCBI登录号
- NM_006565, NP_006556
- UniProt
- P49711
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