HSD17B6 抗体 (N-Term)
(2 references)-
- 抗原 See all HSD17B6 抗体
- HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HSD17B6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
- 预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against HSD17B6. It was validated on Western Blot and immunohistochemistry.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human HSD17B6
- Top Product
- Discover our top product HSD17B6 Primary Antibody
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (AA 1-317) antibody
HSD17B6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (N-Term) antibodyHSD17B6 适用: 人, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) antibodyHSD17B6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (N-Term) antibodyHSD17B6 适用: 人, 小鼠, 犬, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (AA 178-317) antibodyHSD17B6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 317 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer." in: Cancer research, Vol. 71, Issue 4, pp. 1486-96, (2011) (PubMed).
: "Estrogen receptor ? and 17?-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 50, pp. 20090-4, (2011) (PubMed).
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: "Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer." in: Cancer research, Vol. 71, Issue 4, pp. 1486-96, (2011) (PubMed).
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- 抗原
- HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))
- 别名
- HSD17B6 (HSD17B6 产品)
- 别名
- HSE antibody, RODH antibody, SDR9C6 antibody, 17betaHSD9 antibody, Hsd17b9 antibody, Rdh8 antibody, hydroxysteroid 17-beta dehydrogenase 6 antibody, hydroxysteroid (17-beta) dehydrogenase 6 antibody, HSD17B6 antibody, Hsd17b6 antibody
- 背景
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HSD17B6 has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. HSD17B6 is a member of the retinol dehydrogenase family.The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
Alias Symbols: HSE, RODH, SDR9C6
Protein Size: 317 - 分子量
- 35 kDa
- 基因ID
- 8630
- NCBI登录号
- NM_003725, NP_003716
- UniProt
- O14756
- 途径
- Steroid Hormone Biosynthesis
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