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FZD8 抗体 (N-Term)

Name: FZD8 抗体 (N-Term)
SKU: ABIN2776728
Availability: OutOfStock

FZD8 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-FZD8 Antibody Titration: 0. (FZD8 抗体 (N-Term))

Host: Rabbit Target Name: FZD8 Sample Tissue: Human 721_B Antibody Dilution: 1. (FZD8 抗体 (N-Term))

2 images

(2 references)

产品编号 ABIN2776728

发货至: 中国

Datasheet as PDF

抗原 See all FZD8 抗体

FZD8 (Frizzled Family Receptor 8 (FZD8))
抗原表位
7

6

4

3

2

2

1

1

1

1

1

1

1

1

1
N-Term
适用
59

46

34

5

4

1

1

1

1
人, 小鼠, 大鼠, 犬
宿主
57

3

1

1
兔
Compatible Secondaries
克隆类型
53

9
多克隆
标记
28

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This FZD8 antibody is un-conjugated
应用范围
38

17

13

12

11

6

2

1

1
Western Blotting (WB)

序列

PDTLCMDYNR TDLTTAAPSP PRRLPPPPPG EQPPSGSGHG RPPGARPPHR

预测反应

Dog: 100%, Human: 100%, Mouse: 93%, Rat: 92%

产品特性

This is a rabbit polyclonal antibody against FZD8. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8

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Discover our top product FZD8 Primary Antibody
anti-Frizzled Family Receptor 8 (FZD8) (AA 55-233) antibody
FZD8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) antibody
FZD8 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (AA 72-161) antibody
FZD8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (Extracellular Domain) antibody
FZD8 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (N-Term) antibody
FZD8 适用: 人, 小鼠, 大鼠, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (N-Term) antibody
FZD8 适用: 人, 小鼠, 大鼠, Cow, 猴, 非洲爪蟾, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (N-Term) antibody
FZD8 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (C-Term) antibody
Verified FZD8 适用: 人 WB, ELISA, IHC, IF, IEM 宿主: 山羊 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (C-Term) antibody
FZD8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Frizzled Family Receptor 8 (FZD8) (C-Term) antibody
FZD8 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 694 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Xu, Wen, Liu, Xu, Yang, Liu, Feng, An: "MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8." in: Oncotarget, Vol. 7, Issue 26, pp. 40644-40656, (2016) (PubMed).

Yin, Xu, Bonfil, Banerjee, Sarkar, Sethi, Reddy: "Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer." in: Molecular cancer therapeutics, Vol. 12, Issue 4, pp. 491-8, (2013) (PubMed).
抗原

FZD8 (Frizzled Family Receptor 8 (FZD8))

别名

FZD8 (FZD8 产品)

别名

FZ-8 antibody, hFZ8 antibody, FZD8 antibody, Fz-8 antibody, frizzled8 antibody, xfz8 antibody, Xfz8 antibody, frizzled-8 antibody, hfz8 antibody, Fz8 antibody, fzd8 antibody, fz5 antibody, fz8a antibody, fzc antibody, wu:fd02c05 antibody, zg05 antibody, ZG06 antibody, Zfz8b antibody, fz6 antibody, fz8b antibody, fzA antibody, ik:tdsubc_1e1 antibody, xx:tdsubc_1e1 antibody, zfzA antibody, frizzled class receptor 8 antibody, frizzled class receptor 8 S homeolog antibody, frizzled class receptor 8 L homeolog antibody, frizzled class receptor 8a antibody, frizzled class receptor 8b antibody, FZD8 antibody, fzd8.S antibody, fzd8 antibody, Fzd8 antibody, fzd8.L antibody, fzd8a antibody, fzd8b antibody

背景

FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Alias Symbols: FZ-8, hFZ8
Protein Interaction Partner: WNT1, LRP5, LRP6, SUMO1, GOPC, RYK,
Protein Size: 694

分子量

73 kDa

基因ID

8325

NCBI登录号

NM_031866, NP_114072

UniProt

Q9H461

途径

WNT signaling