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MBD4 抗体 (Middle Region)

MBD4 适用: 人, 豚鼠 WB, ChIP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2776028
发货至: 中国
  • 抗原 See all MBD4 抗体
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    抗原表位
    • 9
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 32
    • 5
    • 3
    人, 豚鼠
    宿主
    • 31
    • 1
    • 1
    克隆类型
    • 32
    • 1
    多克隆
    标记
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    This MBD4 antibody is un-conjugated
    应用范围
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    序列
    CSEQKTSGII NKFCSAKDSE HNEKYEDTFL ESEEIGTKVE VVERKEHLHT
    预测反应
    Guinea Pig: 83%, Human: 100%
    产品特性
    This is a rabbit polyclonal antibody against MBD4. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human MBD4
    Top Product
    Discover our top product MBD4 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 580 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    别名
    MBD4 (MBD4 产品)
    别名
    MED1 antibody, Med1 antibody, methyl-CpG binding domain 4, DNA glycosylase antibody, methyl-CpG binding domain protein 4 antibody, methyl-CpG binding domain 4 DNA glycosylase antibody, MBD4 antibody, Mbd4 antibody
    背景
    MBD4 is involved with DNA methylation. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MED1
    Protein Interaction Partner: KDM1A, SUV39H1, HTT, FAS, SUMO2, UBC, CDCA2, Trim27, FADD, MLH1, CSNK2B, DNMT3B, SIN3A, HDAC1,
    Protein Size: 580
    分子量
    66 kDa
    基因ID
    8930
    NCBI登录号
    NM_003925, NP_003916
    UniProt
    O95243
    途径
    DNA Damage Repair
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