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- 抗原 See all MRVI1 抗体
- MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
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抗原表位
- N-Term
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适用
- 人, Cow, 犬, 豚鼠, 马, 小鼠, 兔, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MRVI1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1
- Top Product
- Discover our top product MRVI1 Primary Antibody
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
- 别名
- MRVI1 (MRVI1 产品)
- 别名
- BB115629 antibody, Irag antibody, Ris1 antibody, IRAG antibody, JAW1L antibody, MRV integration site 1 antibody, murine retrovirus integration site 1 homolog antibody, Mrvi1 antibody, MRVI1 antibody
- 背景
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This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803 - 分子量
- 88 kDa
- 基因ID
- 10335
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