HSD11B1 抗体 (N-Term)
(2 references)-
- 抗原 See all HSD11B1 抗体
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠, 犬, 兔, 绵羊, Cow, 马, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HSD11B1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI
- 预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%
- 产品特性
- This is a rabbit polyclonal antibody against HSD11B1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1
- Top Product
- Discover our top product HSD11B1 Primary Antibody
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anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 201-292) antibody
HSD11B1 适用: 人, 小鼠, 大鼠, 马 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) antibodyHSD11B1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibodyHSD11B1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (C-Term) antibodyHSD11B1 适用: 人 WB, IHC (p), ICC, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 25-292) antibodyHSD11B1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibodyHSD11B1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibodyHSD11B1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) antibodyHSD11B1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 77-92) antibodyHSD11B1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (Internal Region) antibodyVerified HSD11B1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 292 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 2, pp. 192-202, (2013) (PubMed).
: "Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1?-induced COX-2 expression in human term myometrial cells." in: PLoS ONE, Vol. 7, Issue 11, pp. e50167, (2012) (PubMed).
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: "Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 2, pp. 192-202, (2013) (PubMed).
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- 抗原
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
- 别名
- HSD11B1 (HSD11B1 产品)
- 别名
- 11-DH antibody, 11-beta-HSD1 antibody, CORTRD2 antibody, HDL antibody, HSD11 antibody, HSD11B antibody, HSD11L antibody, SDR26C1 antibody, hsd11 antibody, hsd11b antibody, LRRGT00065 antibody, hydroxysteroid 11-beta dehydrogenase 1 antibody, hydroxysteroid (11-beta) dehydrogenase 1b antibody, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antibody, HSD11B1 antibody, HSD11B1b antibody, hsd11b1.L antibody, Hsd11b1 antibody
- 背景
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HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
Protein Interaction Partner: GKAP1, CD36,
Protein Size: 292 - 分子量
- 32 kDa
- 基因ID
- 3290
- NCBI登录号
- NM_005525, NP_005516
- UniProt
- P28845
- 途径
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process
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