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OTC 抗体 (N-Term)

OTC 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 绵羊, 兔, 山羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2773791
发货至: 中国
  • 抗原 See all OTC 抗体
    OTC (Ornithine Carbamoyltransferase (OTC))
    抗原表位
    • 15
    • 11
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 36
    • 30
    • 23
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 绵羊, 兔, 山羊, 豚鼠
    宿主
    • 47
    • 7
    克隆类型
    • 47
    • 7
    多克隆
    标记
    • 25
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This OTC antibody is un-conjugated
    应用范围
    • 43
    • 16
    • 14
    • 13
    • 13
    • 10
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    AFRNGHNFMV RNFRCGQPLQ NKVQLKGRDL LTLKNFTGEE IKYMLWLSAD
    预测反应
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%
    产品特性
    This is a rabbit polyclonal antibody against OTC. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human OTC
    Top Product
    Discover our top product OTC Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 354 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hallows, Yu, Smith, Devries, Devires, Ellinger, Someya, Shortreed, Prolla, Markley, Smith, Zhao, Guan, Denu: "Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction." in: Molecular cell, Vol. 41, Issue 2, pp. 139-49, (2011) (PubMed).

    Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." in: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

    Yu, Lin, Yao, Huang, Lei, Xiong, Zhao, Guan: "Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13669-75, (2009) (PubMed).

    Tanaka, Wada, Maruyama, Tanaka, Takikawa, Komatsu: "Hyperammonemia-induced encephalopathy due to ornithine transcarbamylase deficiency in an adult woman: identification of novel missense mutations." in: Journal of gastroenterology, Vol. 40, Issue 1, pp. 106-7, (2005) (PubMed).

  • 抗原
    OTC (Ornithine Carbamoyltransferase (OTC))
    别名
    OTC (OTC 产品)
    别名
    OCTD antibody, 2810428A13Rik antibody, AA589422 antibody, AW457381 antibody, OCT antibody, Plxn2 antibody, mKIAA0463 antibody, F1B16.13 antibody, F1B16_13 antibody, ORNITHINE CARBAMOYLTRANSFERASE antibody, ornithine carbamoyltransferase antibody, BA4351 antibody, PSPTO4164 antibody, PLXN2 antibody, AI265390 antibody, Sf antibody, spf antibody, si:dkey-19h21.3 antibody, ornithine carbamoyltransferase antibody, plexin A2 antibody, ornithine carbamoyltransferase ArgF antibody, ornithine transcarbamylase antibody, OTC antibody, Plxna2 antibody, Otc antibody, argF antibody, argF-2 antibody, atpD-2 antibody, CNC04300 antibody, PLXNA2 antibody, otc antibody
    背景
    OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
    Alias Symbols: OCTD
    Protein Interaction Partner: OTC, TOMM20,
    Protein Size: 354
    分子量
    39 kDa
    基因ID
    5009
    NCBI登录号
    NM_000531, NP_000522
    UniProt
    P00480
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