EC 4.1.2.27, SP-lyase, hSPL or Sphingosine-1-phosphate aldolase. Gene name: SGPL1 or KIAA1252,Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1-phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
纯化方法
Antigen Immunoaffiinity Purification
免疫原
Synthetic peptide derived from the sphingosine 1-phosphate lyase 1 protein.
Antibody can be used for Western blotting (1:400 dilution). Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.
限制
仅限研究用
浓度
Lot specific
缓冲液
Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles